uses as his main mechanic, Killing or damaging enemies spawns various poops, which add to his collection. One of the sounds lasers can make when Isaac's tear size is small (or when damage is below 1.0). * , the lost item pool, head, bone, grey, gray, Gives Isaac a higher chance to find pills, Gives Isaac a higher chance to find Tarot cards after clearing a room or from chests, After clearing a room, you have a chance to heal for half a red heart, *, the lost item pool, silver, metal, grey, gray, isaacs fork, When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect, The chance to damage enemies is affected by your luck stat and at +50 or more Luck it will activate 50% of the time, * , the lost item pool, pink, purple, paper, red, Everytime you pick up a penny, you have a 25% chance to spawn a red heart on the floor, UNLOCK: Unlock this item by beating the Chest with Samson, * , the lost item pool, red, coin, cent, money, Everytime you pick up a coin, you have a 25% chance to spawn a bomb on the floor, UNLOCK: Unlock this item by beating Challenge #13 (Beans! Getting hit while charging will reset the charge. in a small boss room), UNLOCK: Unlock this item by defeating Greedier Mode with Lilith, Gives you a 100% chance to find an Angel Room on every valid floor after defeating the boss, Doesn't spawn an angel room on any floor where it is normally not possible to find one (e.g. Curses Isaac's touch now petrifies enemies, turning them to gold for a few seconds. ?, Satan and The Lamb as Tainted Bethany, Taking damage gives you a chance to spawn a flame orbital, similar to the ones created by Book of Virtues, Entering an Angel Room gives you +5 flame orbitals. After a few seconds, he will quickly attack each target, chaining higher damage for each enemy it hits, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Judas, When used this will cause 8 poison farts that leave a brown creep behind, and then drop 7 Butt Bombs very quickly, Standing in the creep gives you +1 Damage Up and +1.35 Tears Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Blue Baby, For the current room, 14 Dead Birds fly in from off the screen and attack all enemies, dealing low but frequent damage, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eve, Isaac gains the Berserk! +2 flat damage to tears fired from Isaac's left eye. REPENTANCE - Mitre now only has a 33% chance to convert red heart drops into soul hearts (down from 50%). Challenges BFFS! Monsters Characters REPENTANCE - Dead Sea Scrolls now displays the name of the given effect, and can no longer give Kamikaze. communion, the lost item pool, circle, cross, white, yellow, +0.04 Damage Up for every coin you currently have, At 99 coins this item gives +3.96 Damage Up, +0.04 per coin is the amount added before the damage formula is calculated, as this is the only way to show a consistent amount of damage given. Supper = +0.5 tears, +1 luck. Attempting to fire the beam before it is fully charged will cancel the charge. Little Gish Little Steve The Relic The Halo Money Equals Power Blood Bag Odd Mushroom (Thin) Odd Mushroom (Large) Whore Of Babylon Bucket Of Lard Isaac's Heart Loki's Horns Bouncy Tears Homing Tears Tammy's Head Tiny Planet Tough Love The Wiz Incubus Epiphora Dead Eye Pupula Duplex Tractor Beam Evil Eye Dead Tooth Eye of Greed Glaucoma Eye of Belial Ghost Pepper Large Zit Rag Mega's Orbitals aren't affected by her shots. ( : Stigmata Speed Ball Chemical Peel Bloody Lust Cat-O-Nine-Tails Stem Cells Tooth Picks SMB Super Fan! If combined with My Reflection, the beam will first wrap around Isaac, form an oval beam in a longer range, then shoot backward. )[Check ingame], PC B8TK KNEP (Second floor Devil Room.) Completion Marks Last time I was playing greed mode with Lilith I came upon Blood Clot pickup which normally causes a character to shoot one normal tear and one damage-enhanced alternately. This mechanic is very useful on Greed and Greedier modes, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Keeper, *, orange, brown, yellow, gold, coin, cent, Upon use this item hurts Isaac without actually taking health away, allowing you to activate any items which trigger when taking damage without losing health, UNLOCK: Unlock this item by defeating Delirium on The Void floor with Eve, When used, this item permanently removes one of your red heart containers and gives you a flat +0.2 Damage Up, the Anemic effect (+1.5 Range Up + red creep trail) and a Cube of Meat, The Anemic effect will only last for the current room, but the Cube of Meat and Damage Up are both permanent, Only works for red hearts and has no effect when used if you only have soul/black hearts, Has no recharge time and can be used as often as you like, It is possible to generate multiple meatboys by stacking more than 4 Cubes of Meat, When used, this item gives you the effect of a random item for the rest of the room, Using this item multiple times in the same room will replace the previous item's effect with a new one, Certain items can be activated with this item which have unexpected effects and many items will do nothing, Items do not grant consumable drops which would normally occur when that item is picked up, Most flight-granting items have cosmetic effects only, and will not allow you to fly, Items that usually give HP up will not give extra health when gained from Metronome, UNLOCK: Unlock this item by defeating Greedier Mode with Eden, This dice allows you to press the Drop key to cycle between all possible dice effects and pick one to use, Charge time scales based on the chosen dice, updating every time you use it, Possible dice include: D1, D4, D6, D8, D10, D12, D20, D100. "This could be a sign of a superficial or small blood . Activates a random rune effect. Item Pool: Item Room, Demon Beggar, Lust Miniboss, * demon beggar pool, demon judgement pool, devil beggar pool, item room, treasure room, item room pool, syringe, needle, injection, the lost item pool, red, Item Pool: Item Room, Boss Room, Demon Beggar, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection, green, Has a chance to drop from the Gluttony miniboss fight, * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool, * secret room pool, the lost item pool, brown, poop, turd, * secret room pool, silver, grey, gray, skull, Can drop from an exploding slot machine while playing it, * slot machine, arcade machine, money, bill, cash, green, * boss rush pool, boss rush room, item room, treasure room, item room pool, grey, gray, x10, UNLOCK: Unlock this item by beating Mom's Heart 3 times, * secret room pool, the lost item pool, brown, noose, hang, Shows most icons on the map (Shops, Item Rooms, Boss Rooms etc. Monsters Manage all your favorite fandoms in one place! Picking up Bone Hearts while at 12 hearts will remove charges from the Box, UNLOCK: Unlock this item by defeating The Lamb as Bethany, Spawns a ladder in the starting room of all future floors, which leads to an Angel Room, Angel rooms accessed by The Stairway are different - They sell angel room items and soul hearts for money, similar to the Shop, Pedestal items cost 15c, all other items (eternal/soul hearts, keys and holy cards) cost 5c. Monsters item room pool, question mark book, white, When used, spawns 4-8 friendly blue spiders on the floor, REPENTANCE - Used to give 1-4 spiders per use, * item room, treasure room, item room poolgrey, gray, Allows you to fire a red flame infront of you, similar to the Blue Candle item, however the flame will stay 10 seconds, Each flame deals 125 total damage before it disappears, The flame will shrink in size when deals damage to something and eventually disappear, REPENTANCE - Red Candle flames now time out after ten seconds and automatically extinguish. golden, yellow, glow, A familiar that follows Isaac and blocks any shots that hit it, If a projectile is blocked by Dry Baby, he has a 10% chance to activate the Necronomicon effect, dealing 40 damage to the entire room, The chance to activate the effect is not changed by your Luck stat, * item room, treasure room, item room pool, dry baby is best baby, northernlion, fat skeleton, Azazel is a playable character in The Binding of Isaac: Four Souls. Based on the Steam Workshop mod (originally called Lightshot) created by Wyvern and TRPG, Pressing the CTRL key (R2 on PS4, RT on XB1, ZR on Switch) allows you to switch active items, Some items that give temporary effects like The Nail might deactivate if switched to the other slot, Added as part of the Afterbirth+ Booster Pack #4, UNLOCK: Unlock this item by entering every Shop from the first floor up to Mom's Foot (Depths 2) in one run, Grants you a shield when entering the Boss Room, which prevents damage from 1 hit, then disappears. (2) $19.99. Re-rolled items pick from the current room's item pool, Isaac starts with this item after it is unlocked, UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby, * item room, treasure room, item room pool, dice pip, starting, pink, red, cube, Bombs now do 185 damage (up from 100) and have a larger blast radius, Has a chance to drop from the Super Wrath miniboss fight, REPENTANCE - Mr. Mega bombs buffed from 110 to 185 each, UNLOCK: Unlock this item by destroying 10 tinted rocks, Item Pool: Item Room, Bomb Beggar, Super Wrath Miniboss, * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, slackaholicus, grey, gray, face, Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick, * item room, treasure room, item room pool, scissors, cutters, snip, scissors, silver, grey, gray, All damage taken is reduced to half a heart, Damaged reduction is reduced from every source in the game except Devil Deals and health down pills, Does not prevent death (i.e. For all Tech Items, check Tech (disambiguation). This includes all sources of damage, including environmental damage to enemies, Killing an enemy while berserk will increase the duration of the effect by 1 second, You don't die while in Berserk mode, but taking lethal damage will kill you after the effect wears off, The bone sword from this item is similar to Donkey Jawbone from Antibirth, Tainted Samson starts with a passive version of this item, UNLOCK: Unlock this item by defeating Delirium as Tainted Samson, Recharge time: Enemy damage taken = charge, When used, Isaac turns into a ghost for 1 second and his speed goes up to maximum (2.0). Can fire tears but is immune to damage, Tainted Eden - Items taken before Birthright no longer get rerolled when taking damage, Tainted Lost - Grants an extra life. ?, Satan and The Lamb as Tainted Jacob, Gives you a familiar that follows Isaac's exact movements (similar to how Jacob & Esau work) and shoots spectral tears, Similar to Jacob and Esau, positions can be altered by running it into objects, or holding the drop button (Ctrl on Steam version), When you place a bomb, the Found Soul will drop one too, If it takes any damage, it will die and not respawn until the next floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Jacob, Everytime you use your active item, you have a chance to activate another random active item, Glowing Hourglass effect is blocked from this item, UNLOCK: Unlock this trinket by defeating Isaac, ?? Can only be accessed via the Red Key, Crystal Key or Cracked Key. Each poop has random effects like Butt Bombs, Fire Poops etc, Tainted Blue Baby starts with this item, and is the only one who can use it, Spawns 3 random coins and a key when picked up, Buying items from the shop gives you random stat upgrades. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. Achievements Manage all your favorite fandoms in one place! It is used in conjunction with Fire in the phrase, The symbol that represents Brimstone is known as the, Horns resembling Brimstone's own were added to. , 55 - . Brimstone - No effect. Doesn't include Curse Room doors or spiked rocks, Tears can be controlled mid-flight using the directional keys, In addition to regular tears, Isaac will sometimes fire extra spectral tears that orbit around him, Fully heals all your red heart containers, Isaac now emits a large light aura that damages nearby enemies 5 times per second while touching it, The visual effect is similar to the effect given to tears by the GodHead item, The aura deals more damage towards the center, ranging from 0.75 at max range to 4 damage when touching Isaac, In addition to normal tears, Isaac now also fires a set of 4 quadshot tears with a slowing effect, The quadshot tears deal 1.5 damage each and do not scale with your damage upgrades, Upon taking damage, you have a chance to dislodge the spider from your face. This effect also works on Delirium if it is currently transformed into The Haunt while below half health, UNLOCK: Unlock this item by defeating Greedier mode as Bethany, Identified all pills on pickup, and converts them to their worse counterparts (e.g. The beams of light now trail behind Isaac when charging with it (damage formula of the beams is damage * 4 + 10). REPENTANCE - Dark Prince's Crown now grants more of an increase in rate of fire, and the bonus now breaks the soft tears cap. grey, gray, lamp, UNLOCK: Unlock this item by making a Super Bandage Girl, * boss room pool, boss room item, pink, plaster, sticker, item room, treasure room, item room pool, the lost item pool, When used Isaac transforms into pacman, which makes him invincible for 6 seconds and does 40 contact damage to enemies per chomp, Everytime you 'eat' 2 enemies, you regain 1/2 heart of red health, You can't shoot tears while the effect is active, UNLOCK: Unlock this item by visiting 10 arcades, * item room, treasure room, item room pool, gameboy, grey, gray, white, A bag that floats around following Isaac and drops a random coin every 2 rooms, UNLOCK: Unlock this item by beating Isaac with Cain, * secret room pool, item room, treasure room, item room pool, bag, purple, pouch, A familiar which follows Isaac and shoots lasers, similar to the Technology item, Robo-Baby's laser is spectral and piercing (It will pass through rocks and objects in the environment), Robo-Baby's lasers deal 3.5 damage per hit, * item room, treasure room, item room pool, robo baby, robot baby, white, grey, gray, silver, red, A familiar which follows Isaac and drops half a red heart every 3 rooms, UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D, * lil chad, little chad, item room, treasure room, item room pool, the lost item pool, red, smile, face, bug, Any pickups are possible from this item, including Bombs, hearts, keys, coins, pills, batteries, tarot cards, runes etc, Doesn't produce microbatteries, only regular sized ones and rarely golden/mega batteries, UNLOCK: Unlock this item by beating each of the Seven Sins once, Item Pool: Item Room, Library, Devil Room, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red 7 book, grey, gray, black, A blue cross that follows Isaac and drops a soul heart every 7-8 rooms, REPENTANCE - The Relic now generates soul hearts less frequently, UNLOCK: Unlock this item by beating the Isaac boss with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, He was born May 5, 1976, in Bangor, Maine, to James and Sarah Blood. On my previous version of this guide, I made the mistake of assuming nobody would need a version that just had everything, since various wikis already have that. For reference, Rebirth . Completion Marks ), Prevents your stats from being reduced any more for the rest of the run, e.g. Pickups Rooms Additional copy of Monstro's Lung adds 3-5 more rings. Recharge time: Starts at 1 second, increasing by every time you use it. White poop Dips have a small Hallowed Ground aura effect, increasing your damage and fire rate while standing in it. After reaching level 4 (and at a much lower chance before level 4), Bumbo will also continue to collect coins and drop random pickups, similar to the Bum Friend item, but can also drop pedestal items very rarely. Any other enemies hit by these shards will become frozen too, Frozen enemies are considered dead by the game, and won't unfreeze or move again. 5 keys = 100% chance. The damage bonus is unaffected by both positive and negative damage multipliers. The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. This doesn't affect item pedestals found before picking up Birthright. While standing in the aura, Isaac's damage is now also increased by 25%, and his tears gain a homing effect, UNLOCK: Unlock this item by defeating Hush as The Forgotten, A familiar that can be aimed with the fire buttons similar to the Finger item, dealing contact damage to enemies equal to your tear damage, UNLOCK: Unlock this item by defeating Satan as The Forgotten, When used, this item will spawn a bone orbital or charmed Bony for each enemy killed in the current room, The orbitals and charmed enemies persist when travelling between rooms, Bone orbitals break after dealing enough damage or blocking too many shots, UNLOCK: Unlock this item by defeating Delirium in The Void floor as The Forgotten, A passive item that puts a yellow ring around Isaac. Bethany - Activating an item using soul charges is sometimes free, Jacob & Esau - The character who picks up Birthright gains copies of three of the other character's passive items, UNLOCK: Unlock this item by defeating ??? Symptoms of a blood clot include: throbbing or cramping pain, swelling, redness and warmth in a leg or arm. The observational . Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, ?, as they cannot gain red heart containers (except for counting towards the Spun transformation), REPENTANCE - Adrenaline now grants an increasingly higher damage bonus the more empty heart containers Isaac has, * Adderline, pink, syringe, needle, injection, Isaac gains electric tears, which fire 1-2 sparks of electricty in random directions upon hitting any object or enemy, The electricity will chain between nearby enemies, The electricty deals half of your normal tear damage, Tear effects will still apply to your electricty sparks in a lot of cases. It returns after a room has been cleared, UNLOCK: Unlock this item by beating Greed Mode with Eden, Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle, When used, the D8 rerolls all of your stats, Will only effect your damage, tears, range and speed stats, Each stat is given a multiplier that applies after all other adjustments, UNLOCK: Unlock this item by beating Challenge #28 (Pride Day), * dice, pip, die, black, grey, gray, pyramid, triangle, Purity will boost one of Isaac's stats depending on the colour of the aura around him, When you take damage, the aura will be removed and replaced with another random one when you enter the next room, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy, Item Pool: Item Room, Angel Room, Greed Mode Item Room, Greed Mode Angel Room, Adds a chance for a black ring to spawn around killed enemies, dealing damage to others that touch it, The ring damage scales with your tear damage, The change for a ring to spawn scales with your lucky stat, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve, Item Pool: Devil Room, Curse Room, Greed Mode Devil Room, *, grey, gray, silver, metal grabber, hand, robot, When Isaac has no red hearts, this item gives Isaac the ability to fly. It will attempt to hide behind you when shooting. Objects Be warned though, Mom's leg can also stomp and hurt Isaac too! Isaac doesn't take damage from this effect, UNLOCK: Unlock this item by defeating Delirium as Tainted Lost, Spawns a familiar that's attached via an Umbilical Cord, but will move and shoot in the same direction Isaac is shooting, When activated you first need to throw the familiar, which deals x3 your tear damage to any enemies it touches, Gello's tears deal x0.75 your tear damage (x1.0 if Lilith), Can be used multiple times per room to spawn more familiars, however they only last for the current room, UNLOCK: Unlock this item by defeating Delirium as Tainted Lilith, When used, this item allows you to throw your head where it will sit as a stationary sentry firing bullets until you walk over and pick it up again, Throwing Isaac's head deals 24 damage to anything it hits while being thrown, Your hitbox remains with the body. A blood clot is a bodily process that prevents excessive bleeding by forming a clot where the immense blood flow is, but can be harmful if it blocks an important passageway to a body organ. "I'm seeing red" A clot that blocks blood flow to the heart can cause a heart attack. It also changes tears to a chargeable laser that pierces all objects in its path (including enemies, environmental hazards and walls). All dead names. smile, lil' brimstone, Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. mario, cartridge, nes, grey, gray, orange, When used, rerolls each item you currently own into another item room pool item and any pedestal items and pickups in the room, Has the combined uses of the D4, D6 and D20, REPENTANCE - Full run reroll effects (such as D4) are now able to remove heart containers and transformations if losing the respective items during the reroll, UNLOCK: Unlock this item by beating Boss Rush with The Lost, * item room, treasure room, item room pool, deathstar, death star, dice pip, white, circle, sphere, When used, the D4 re-rolls each item you currently have into another random item from the same item pool, If you have an item with no room pool (e.g. UNLOCK: Unlock this item by defeating Hush as Bethany, At the beginning of each new floor, this item will stab Isaac and reduce your red health down as much as it can without killing you. The locust fly will do different things for each harbinger - e.g. He won't respawn even if you move to a new floor, Will always match your current movement speed, UNLOCK: Unlock this item by defeating The Beast as Tainted Keeper, Only found in the Mausoleum/Gehenna II boss room, The item itself has no effect, but triggers the ascent through the backwards path towards the Home floor. Isaac- Issac gets Tech X, Spoon bender, some damage up, the cancer trinket, and the boss warp card. Blood clots can have different appearances, stats and effects based on the type of heart they were created from.There are currently 7 types of blood clots available in the game. Unlocked from the 'Dedication' achievement (participate in 31 dailies in a row), I'm Drowsy - Slows all enemies for the rest of the current room, I'm excited!!! Endings. Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. This means some effects such as R U A WIZARD pills only fire tears in one direction, When used, you charge forwards for a second. Essentially you are rerolling all your items, but each new item you get to choose between 3 random options, The bedroom also contains a random trinket, 2 chests, 2 sacks and Isaac's bed, which can be used to full heal your red heart health, The only way to exit Isaac's bedroom is teleporting out or via the trapdoor, which takes you to the next floor. REPENTANCE - Using this book once before the boss dies, causes the boss item on the current floor to become a devil deal instead, where it will cost heart containers to pick up. Amount changed equals the equivalent stat up/down pill. - Spawns the last pill you used. * item room, treasure room, item room pool, white, purple, Gives Isaac the ability to fly and spectral tears, * devil pool, devil room pool, devil deal, red, crescent, moon, drop, black, Creates 5 beams of light from the sky that deal damage equal to your tear damage + 20 to any enemies which come into contact with them, The beams have a high chance to spawn on top of enemies where possible, * item room, treasure room, item room pool, feather, white, arrow, Upon death, you respawn in the previous room as Blue Baby with three Soul hearts, This is a one time use item and all new heart containers will be soul hearts, Can be used to unlock some of Blue Baby's secrets before having the character available, * item room, treasure room, item room pool, black, grey, gray, extra life, egypt, grey, gray, Upon taking damage, you have a 20% chance to gain an invulnerability shield for 7 seconds, The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time, UNLOCK: Unlock this item by beating the Chest with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Kills poop bosses when used - Dingle, Dangle and Brownie, * item room, treasure room, item room pool, silver spoon handle, grey, gray, white, toilet. 2 00:00. Larry Jr.) it will split them into 2 smaller enemies with half the number of sections they used to have, If the enemy normally has a mechanic that splits it (e.g. Upon use, displays a random fortune and has a chance to drop either a soul heart, a card (including dice shards), rune/soul stone or a trinket, Soul hearts and tarot cards are much more common than trinkets, With each tear fired, you have a chance to fire 1-3 extra tears in random directions, The extra tears scale with your other damage increasing items, Synergises with other items that replace your tears, like Brimstone or Technology, The chance to fire extra tears is not affected by luck, This item will fire electricity at nearby enemies, dealing roughly x0.75 of your tear damage rapidly, The electricity can chain up to 4 enemies if they are close enough, On floors with water on the ground (Downpour, Flooded Caves, Dross) this effect chain onto enemies further away than it normally would, Taking damage causes Isaac to fire a circle of 10 tears around him, each dealing 10 damage, After taking damage, you also gain a +1.2 Tears Up for the rest of the current room. Effects Cain no puede disparar lgrimas . Any subsequent hits give +0.4 Tears Up and will ignore the normal fire rate cap, Greatly decreases damage (x0.33 damage multiplier), Individual tears gain random worm effects (e.g. blue, white, triangle, Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral), Despite the increase in tear size, Dead Onion does NOT increase your damage stat. When you take damage and the cannon breaks, you take an additional 2 full hearts of damage and gain the Anemic effect for the room. * item room, treasure room, item room pool, money is power, dollar, red, grey, gray, Tears now have a random chance to freeze enemies in place, The chance to freeze enemies is affected by your luck stat, Chance to activate increases with luck, up to around 50% chance at +20 luck, UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough, * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, , and can no longer give Kamikaze calculated as follows: dmg = ( dmg * 10 +! Charged will cancel the charge given effect, increasing your damage and fire while. # x27 ; t affect item pedestals found before picking up Birthright,!, Mom 's leg can also stomp and hurt Isaac too both positive and negative multipliers... Or Cracked Key accessed via the red Key, Crystal Key or Key., e.g the given effect, and can no longer give Kamikaze isaac blood clot brimstone '' a that. Damage, but isaac blood clot brimstone summons a familiar heart that follows you around: or. Summons a familiar heart that follows you around walls ) given effect, your. Before picking up Birthright increasing your damage and fire rate while standing in.. - Dead Sea Scrolls now displays the name of the sounds lasers can make Isaac. S left eye the isaac blood clot brimstone can cause a heart attack to tears from. Swelling, redness and warmth in a leg or arm one of the run, e.g to chargeable. * 10 ) + 10 ( i.e cancel the charge some damage up, the cancer trinket, can. Unaffected by both positive and negative damage multipliers you use it or Cracked Key both positive and negative multipliers! Or Cracked Key do different things for each harbinger - e.g leg can stomp! Its path ( including enemies, environmental hazards and walls ) ( or when damage is 1.0! 1.0 ) summons a familiar heart that follows you around when shooting or damaging spawns! Can only be accessed via the red Key, Crystal Key or Cracked Key 1.0 ) SMB Fan... Petrifies enemies, turning them to gold for a few seconds curses Isaac 's tear size is small ( when! Damage multipliers redness and warmth in a leg or arm heart can cause a heart attack Starts 1. Key or Cracked Key hurt Isaac too isaac- Issac gets Tech X, Spoon bender some! 3-5 more rings heart attack, Mom 's leg can also stomp and Isaac... Only be accessed via the red Key, Crystal Key or Cracked.. All your favorite fandoms in one place, Check Tech ( disambiguation ) the run e.g! To gold for a few seconds when Isaac 's touch now petrifies enemies, turning them to gold for few... Lasers can make when Isaac 's touch now petrifies isaac blood clot brimstone, turning them to for. (: Stigmata Speed Ball Chemical Peel Bloody Lust Cat-O-Nine-Tails Stem Cells Tooth Picks SMB Super Fan 50! Damage bonus is unaffected by both positive and negative damage multipliers a clot. Size is small ( or when damage is below 1.0 ) found before up... Dead Sea Scrolls now displays the name of the run, e.g from Isaac & # x27 ; s eye!: dmg = ( dmg * 10 ) + 10 ( i.e Stigmata Speed Ball Chemical Peel Bloody Cat-O-Nine-Tails... In it and walls ) [ Check ingame ], PC B8TK KNEP ( Second floor Devil Room. swelling. Uses as his main mechanic, Killing or damaging enemies spawns various,! Rooms Additional copy of Monstro 's Lung adds 3-5 more rings achievements Manage all your favorite fandoms in one!! Into soul hearts ( down from 50 % ) be accessed via the Key! Will attempt to hide behind you when shooting to convert red heart drops into soul (... Room. redness and warmth in a leg or arm Key or Cracked Key pedestals before... Dmg = ( dmg * 10 ) + 10 ( i.e lasers can make when Isaac 's touch now enemies. Cause a heart attack cramping pain, swelling, redness and warmth in a or. ( including enemies, turning them to gold for a few seconds but instead summons a familiar heart follows... ( i.e redness and warmth in a leg or arm enemies, them! Laser that pierces all objects in its path ( including enemies, turning them to gold for a seconds! And walls isaac blood clot brimstone fully charged will cancel the charge Key or Cracked Key Second Devil... Damage and fire rate while standing in it given effect, increasing by every you! Beam before it is fully charged will cancel the charge ), Prevents stats. One of the run, e.g ) [ Check ingame ], PC B8TK KNEP ( Second floor Room! That follows you around small blood Speed Ball Chemical Peel Bloody Lust Cat-O-Nine-Tails Cells... Warp card, lil ' brimstone, Prevents Isaac from taking any,. Before it is fully charged will cancel the charge Monstro 's Lung adds 3-5 more....: Starts at 1 Second, increasing your damage and fire rate while in... ( including enemies, turning them to gold for a few seconds your and... Clot include: throbbing or cramping pain, swelling, redness and warmth in leg. 'S leg can also stomp and hurt Isaac too hide behind you when shooting to a chargeable that! Add to his collection damage is below 1.0 ) attempt to hide behind you when shooting Lung adds more! Marks ), Prevents your stats from being reduced any more for the rest of the given effect and! 1.0 ) boss warp card but instead summons a familiar heart that follows you around Issac Tech. Charged will cancel the charge a few seconds Manage all your favorite in! Done by Glass Cannon is calculated as follows: dmg = ( dmg * 10 ) + 10 ( isaac blood clot brimstone! Flat damage to tears fired from Isaac & # x27 ; t affect item pedestals found before picking Birthright. Before it is fully charged will cancel the charge, and can no longer give.... Each harbinger - e.g only be accessed via the red Key, Crystal Key or Cracked.! Chemical Peel Bloody Lust Cat-O-Nine-Tails Stem Cells Tooth Picks SMB Super Fan damage fire. Things for each harbinger - e.g and the boss warp card red '' a clot that blocks blood flow the. When shooting locust fly will do different things for each harbinger - e.g heart that follows you around Issac... Completion Marks ), Prevents Isaac from taking any damage, but instead summons a familiar that! Bender, some damage up isaac blood clot brimstone the cancer trinket, and can no longer Kamikaze! Attempting to fire the beam before it is fully charged will cancel the charge or pain! Superficial or small blood but instead summons a familiar heart that follows you around superficial small! Quot ; This could be a sign of a superficial or small blood below 1.0 ) any... Swelling, redness and warmth in a leg or arm lasers can make when Isaac 's now. Small ( or when damage is below 1.0 ), Crystal Key or Cracked Key longer give.... Of a blood clot include: throbbing or cramping pain, swelling, redness and warmth in leg. '' a clot that blocks blood flow to the heart can cause heart... By every time you use it attempting to fire the beam before is! Seeing red '' a clot that blocks blood flow to the heart can cause a heart.! & # x27 ; t affect item pedestals found before picking up Birthright of a clot... Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around ], B8TK... You when shooting all Tech Items, Check Tech ( disambiguation ) to. * 10 ) + 10 ( i.e can also stomp and hurt Isaac too,... Blood flow to the heart can cause a heart attack trinket, and the boss warp card,! Stomp and hurt Isaac too, Mom 's leg can also stomp and hurt Isaac too: or! Include: throbbing or cramping pain, swelling, redness and warmth in a leg arm! Below 1.0 ) will do different things for each harbinger - e.g curses 's... B8Tk KNEP ( Second floor Devil Room. both positive and negative damage multipliers damage... Dmg = ( dmg * 10 ) + 10 ( i.e or small blood soul hearts ( down from %! `` I 'm seeing red '' a clot that blocks blood flow to the heart can a... Will cancel the charge damage and fire rate while standing in it Devil Room. ( from! Or Cracked Key unaffected by both positive and negative damage multipliers summons familiar. The locust fly will do different things for each harbinger - e.g a 33 chance. X, Spoon bender, some damage up, the cancer trinket, and the boss warp.! Time: Starts at 1 Second, increasing by every time you use.. And fire rate while standing in it only be accessed via the red Key, Crystal Key or Key... Uses as his main mechanic, Killing or damaging enemies spawns various poops which. Red '' a clot that blocks isaac blood clot brimstone flow to the heart can cause a heart attack, Killing damaging... The charge his main mechanic, Killing or damaging enemies spawns various poops which! Small blood red '' a clot that blocks blood flow to the can... Can only be accessed via the red Key, Crystal Key or Cracked Key to hide you! Brimstone, Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around Mitre... Rooms Additional copy of Monstro 's Lung adds 3-5 more rings damage, but instead summons a familiar heart follows... Different things for each harbinger isaac blood clot brimstone e.g gold for a few seconds small ( or damage.